| Customization: | Available |
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| CAS No.: | 302-79-4 |
| Formula: | C20h28o2 |
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Introduction:
Tretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia. It is also available as a generic.
Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene.
This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia.
ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.
Application:
| Melting point | 180-181 °C(lit.) |
| Boiling point | 381.66°C (rough estimate) |
| density | 1.0597 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, soluble in slightly soluble in ethanol (96 per cent). |
| pka | 4.73±0.33(Predicted) |
| form | powder |
| color | yellow |
| Water Solubility | insoluble |
| Sensitive | Light Sensitive |
| BRN | 2057223 |
| Stability: | Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months. |
Packaging:
Shipping:
Q1:May I get one simple before placing order?
For those high value products, you just need to freight and certain productcost. When we both cooperate for some times or when you are our VIPcustomer, free sample will be offered when you need.
Q2:Which payment is available for your company?
Re: T/T, L/C trade insurance. You can choose the one which isconvenient for you.
Q3.:How and when can l get my goods after payment?
Re: For small quantity products, they will be delivered to you byinternational courier(DHL, FedEx, TNT etc.) or by air. Usually it will cost3-5days that you can get the goods after delivery.For large quantityproducts,shipping by see is worthwhile.lt will cost days to weeks to come toyour destination port, which depends on where the port is.
Q4: Is there any possible to use my appointed label or package?
Re: Yes. lf needed, we'd like to use label or package according to yourrequirement.
Q5: How can you guarantee the goods you offer is qualified?
Re: We always believe honesty and responsibility are basis of onecompany, so whatever products we provide for you all are qualified. We willhave goods tested and provide COA before delivery for sure.
After Sales Service:
NO.1.Our company guarantes that the products that leave the factory are produced and inspected accrding to the relevant national standards and the ungualitfed productswll never leave the factory. Guarantee the strict implementation and fulfilment ofproduct quality, and strictly implement relevant regulations on product afer-salesservice.
NO.2. the customer raises objection to the quality ofou company's products, we promises to respond within 24 hours afer reciving the user's objection Ifthe quality ofour company's products does not meet the promise, we are willing to refund the payment.
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